GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs2243480 | 1 | rs937108 | chr7:65428452 | CCT6P1 | chr7:65216092-65228661:+ | 0.62 | 5.13 | 1.51E-6 | Diabetic kidney disease |
| THYM | cis | rs9381040 | 1 | rs9381040 | chr6:41154650 | LOC221442 | chr6:41068773-41108567:+ | 0.36 | 5.32 | 6.89E-7 | Alzheimer's disease (late onset) |
| THYM | cis | rs9369898 | 1 | rs9381784 | chr6:49398115 | CENPQ | chr6:49431096-49460820:+ | 0.3 | 5.33 | 6.54E-7 | Homocysteine levels |
| THYM | cis | rs1401999 | 1 | rs939336 | chr3:183685534 | ABCC5 | chr3:183637726-183735727:- | 0.48 | 4.28 | 4.53E-5 | Anterior chamber depth |
| THYM | cis | rs1401999 | 1 | rs939338 | chr3:183704068 | ABCC5 | chr3:183637726-183735727:- | -0.5 | -4.43 | 2.5E-5 | Anterior chamber depth |
| THYM | cis | rs9394931 | 1 | rs9394931 | chr6:42873245 | GNMT | chr6:42928500-42931617:+ | 0.33 | 5.63 | 1.81E-7 | Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) |
| THYM | cis | rs9394931 | 1 | rs9394931 | chr6:42873245 | PEX6 | chr6:42931613-42946981:- | -0.43 | -4.43 | 2.5E-5 | Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) |
| THYM | cis | rs9369898 | 1 | rs9395493 | chr6:49427409 | CENPQ | chr6:49431096-49460820:+ | -0.29 | -5.57 | 2.36E-7 | Homocysteine levels |
| THYM | cis | rs9815354 | 1 | rs939558 | chr3:41976040 | ULK4 | chr3:41288091-42003660:- | -1.02 | -11.59 | 6.88E-20 | Diastolic blood pressure |
| THYM | cis | rs1875620 | 1 | rs9410258 | chr9:91545917 | C9orf47 | chr9:91605778-91611055:+ | -0.27 | -4.75 | 7.31E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs1875620 | 1 | rs9410260 | chr9:91549376 | C9orf47 | chr9:91605778-91611055:+ | -0.26 | -4.7 | 8.7E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs1875620 | 1 | rs9410261 | chr9:91551028 | C9orf47 | chr9:91605778-91611055:+ | -0.26 | -4.68 | 9.7E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs1875620 | 1 | rs9410263 | chr9:91554638 | C9orf47 | chr9:91605778-91611055:+ | -0.26 | -4.68 | 9.7E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs1875620 | 1 | rs9410264 | chr9:91554748 | C9orf47 | chr9:91605778-91611055:+ | -0.26 | -4.68 | 9.7E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs1875620 | 1 | rs9410272 | chr9:91556897 | C9orf47 | chr9:91605778-91611055:+ | -0.27 | -4.71 | 8.28E-6 | Response to statins (LDL cholesterol change) |